In the LSD-bound crystal structure, the aspect chain of your lid residue L209EL2 kinds substantial hydrophobic contacts with both of those LSD and bordering residues in TMs III, IV, and V (Determine 4C). If the lid moved apart to expose the binding pocket in simulation, several of such contacts broke. https://remingtondhvbk.bloggadores.com/34256949/considerations-to-know-about-lsd-vial