And lastly, clonidine enhances neuraxial opioids and, in combination with fentanyl, interacts in an additive fashion, which can reduce the dose of each element by 60% for postoperative analgesia. Severe Allergic Reactions. Clonidine could bring about allergic reactions, which can be major. Cease taking clonidine and acquire assistance straight https://www.proleviate.com/post/the-new-pain-killer-conolidine