Butabarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of CYP3A4 inducers could lessen sufentanil concentrations and efficacy, perhaps precipitating withdrawal syndrome in patients that have made physical dependence to sufentanil. Discontinuation of concomitantly made use of CYP3A4 in... https://rogerf307lfc9.blogofchange.com/profile