Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals in the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions, whic... https://mahatmaq642owd9.blogchaat.com/profile